[ effect of different intensities running on serum glucose and Insulin concentrations in two types of obesity]

Introduction: attention to the relationship between obesity and type PARALLEL TO diabetes and also lack of enough data on the evaluation of obese individual's glucose and insulin responses to different exercise intensities, the present cross sectional study aimed to examine the effects of different intensities running on plasma glucose and insulin concentrations in two levels of obesity in sedentary male students at Sharif University of Technology.

Materials and Methods: Six men in class ? obese and five men in class PARALLEL TO obese ran on the treadmill with progressive intensities of 50, 60, 70, and 80% of VO2max for 10, 10, 5, and 2 minutes, respectively. Blood samples were collected before, during exercise and at 30, 60, and 120 minutes during recovery period. Repeated-measures, two-factor ANOVA, dependent and paired ttests were used to assess both between group and intergroup differences. Statistical significance was accepted at the 5% level.

Results: Plasma glucose concentrations of both groups were unchanged until 70% and increased at 80% compare to resting values but there were observed no significant differences during recovery. Plasma insulin concentrations decreased before 60% in both groups and rose after that and significantly differed to the resting values at 80% which remained significant just half an hour after the exercise cessation.

Discussion: Considering the similar effects of running at 80% VO2max on elevation of glucose and insulin concentrations in both levels of obesity, conducting an experience on diabetic's patients may help to find a proper manner for prevention and more effective treatment.

Possible role for growth hormone in suppressing acylated ghrelin and hunger ratings during and after intermittent exercise of different intensities in obese individuals

Body weight is influenced by both food intake and energy expenditure. Acylated ghrelin enhances appetite, and its circulating level is suppressed by Growth Hormone. Data on the acylated ghrelin responses to exercise of different intensities in obese individuals are currently not available. This study examined the effects of an intermittent exercise protocol on acylated ghrelin levels and hunger ratings in obese people. Nine inactive male ran on the treadmill at 0900 with progressive intensities of 50, 60, 70, and 80% of VO[2]max for 10, 10, 5, and 2 min respectively. Blood samples were collected before the exercise at 0845 [-15 min as the resting values], after each workload [10, 23, 31, and 36 min during exercise], and at 30, 60, and 120 min thereafter. The control trial was conducted under identical conditions with the exception of exercise. Compared to the baseline, both acylated ghrelin levels and hunger ratings were suppressed at 70% of VO[2]max during exercise [17.74 vs. 9.80 pmol/L and 4.84 vs. 2.96 unit respectively] and remained significantly lower than the control trial 2 h after the cessation of exercise [13.95 vs. 20.32 pmol/L and 3.33 vs. 6.04 unit, respectively]. Growth Hormone increased during the exercise period and peaked at 80% of VO[2]max. These findings indicate that acylated ghrelin concentrations and hunger ratings are suppressed during exercise and two hours thereafter in obese individuals, and it is possible that Growth Hormone caused the suppression of acylated ghrelin

[Comparison of the effects of growth hormone on acylated ghrelin and following acute intermittent exercise in two levels of obesity]

The prevalence of obesity has risen enormously over the past few decades. Both food intake [Appetite] and energy expenditure can influence body weight. Acylated ghrelin enhances appetite, and its plasma level is suppressed by growth hormone. The present study, examines the effects of an intermittent exercise with progressive intensities on acylated ghrelin, appetite, and growth hormone in inactive male students with two levels of obesity. Eleven inactive males were allocated into two groups on the basis of their body mass index [BMI]. Six subjects in group one, BMI=31.18 +/- 0.92 kg/m[2], and five subjects in group two, BMI=36.94 +/- 2.25 kg/m[2], ran on the treadmill with progressive intensities of 50, 60, 70 and 80% of VO2max for 10, 10, 5, and 2 min respectively. Blood samples were collected before the exercise [as the resting values], after each workload [during the exercise], and at 30, 60, and 120 min [during recovery]. Plasma acylated ghrelin concentrations and hunger ratings in two groups were decreased and remained significantly lower than resting values [P=0.008 and P=0.002 respectively] at the end of the trial and there was no significant differences between groups. Growth hormone levels in two groups were increased and remained significantly higher than resting values [groups one P=0.012, group two P=0.005] at the end of the trial and there was no significant differences between groups. In addition, there were no significant differences between area under the curves [AUC] values over total periods for acylated ghrelin, hunger ratings, and growth hormone in two groups. These findings indicate that individuals with two levels of obesity have the same response to the different intensities of treadmill running and two hours thereafter during recovery period, which can be considered for designing a more effective weighting loss training program.